Background: Induction of labour is an important procedure in obstetric practice which is indicated when the benefits to the mother or fetus outweigh the benefits of continuing the pregnancy. Attempted induction with an unripe (unfavourable) cervix seldom results in success. Cervical ripening is therefore a prerequisite for successful induction. Vaginal Misoprostol and Foley’s catheter are the most popular methods of cervical ripening for induction of labour in the tropics with varying efficacies hence the need to study the benefits and safety of combining the two methods for pre-induction cervical ripening and induction of labour. Aim: To compare the efficacy and safety of vaginal misoprostol alone, Foley’s catheter alone and combined use of vaginal misoprostol with Foley’s catheter for pre-induction cervical ripening and induction of labour. Methodology: This was a prospective randomized controlled clinical study involving 117 women admitted at term and beyond for induction of labour at the Department of Obstetrics and Gynaecology of the University of Ilorin Teaching Hospital between December 2017 and October 2018. The subjects were randomized into 3 groups; for cervical ripening and induction of labour with any of the three methods (A-vaginal misoprostol alone, B-Foley’s catheter alone or Ccombination of both methods). Interviewer-administered proforma was used to collect data and the comparative statistical analysis of efficacy and safety profiles of the three methods were done using IBM SPSS (version 23.0; Chicago, Illinois, USA). The Categorical variables were presented as proportions and analysed using Chi- square while Continuous variables (e.g. the induction to delivery interval) were presented as mean and analyzed using Independent Samples T test and ii Analysis of Variance (ANOVA) with LSD (Least Significant Difference) Post Hoc test as appropriate. Continuous variables that were not normally distributed were presented as median and analyzed using Kruskal Wallis test. Level of statistical significance was set at p< 0.05 at confidence interval of 95% for all inferential statistics.