Background: IOL is an important procedure in obstetrics. Vaginal Misoprostol is the most popular route for IOL with varying efficacy and safety, hence the need to study other route of misoprostol (oral) for IOL. Aim: To compare time of onset of adequate uterine contraction and induction-to-delivery interval of oral and vaginal misoprostol for IOL. Methods: A hospital-based quasi-experimental study of women with singleton fetus who had IOL at 37 to 41weeks+6days. Participants were assigned into group I (oral) and group II (vaginal) routes; each participant received 25microgram of misoprostol four-hourly till adequate uterine contraction was achieved or a maximum of six doses. Uterine contractions were monitored for adequacy by digital palpation and labour was with the aid of partograph. Data analysis was with SPSS (version 23.0), it included comparative statistical analysis of efficacy and safety profiles of the routes of administration. Categorical variable were represented as proportion and analyzed using Chi-square test, while Fisher exact was used when more than 20% of expected counts were less than 5, continuous variables were presented as mean and analyzed using Independent Samples T test while Kaplan Meier curve was drawn to show timing of deliveries. The level of statistical significance was set at p< 0.05 at 95% confidence interval for all inferential statistics.