Background and Objective Induction of labour is a common intervention performed in cases when continuing a pregnancy present clear health and safety risk to the mother and or her fetus. Around 20% of all deliveries are preceeded by labour induction, a proportion that has not varied dramatically over recent years. Safety, success and patient’s satisfaction are the major objective with economic evaluation becoming a significant factor in search for an ideal induction method. Misoprostol is an oral prostaglandin compound, structurally related to prostaglandin E1, and manufactured as a treatment for peptic ulcer disease in patients on chronic use of nonsteriodal anti-inflammatory drugs. Though unlicenced for this indication, misoprostol is now being used increasingly in induction of labour, with vaginal and oral administrations. This randomised controlled trial is done to ascertain the effectiveness and safety of the route of administration of misoprostol (oral versus vaginal) in induction of labour in Port Harcourt South- South Nigeria. Subject and Method A prospective study (Randomized Controlled Trial) involving booked antenatal cases. The experimental group consisted of eligible women billed for induction of labour. An informed consent was obtained from the patients. A logbook of patient was prepared containing details such as hospital number, age, and trial number. A profoma was also prepared for each participant. On admission into the labour ward, each eligible woman was allocated to one of the experimental groups (oral) or (vaginal route) entirely by chance following randomization sequence. (discussed below).