Introduction: Sickle cell disease in pregnancy carries an increased risk of maternal and perinatal morbidity and mortality. The complications that have been reported include anaemia, gestational hypertension, preeclampsia, severe crisis, postpartum haemorrhage, pulmonary diseases, preterm delivery, low birth weight, fetal distress in labour. Past studies have been limited by relatively small sample sizes or retrospective data, narrow geographic area and use of hospital discharge data. This study was prospective and compared the pregnant SS women with AA controls in order to precisely identify the complications that these women undergo. Aim: This study aimed at determining maternal and fetal complications and outcome of pregnancy in HbSS and HbAA pregnant women and identified associated factors. Methodology: Pregnant women were recruited from the antenatal clinics during booking and follow-up clinics. Information about each was collected on a proforma and subjected to statistical analysis using Epi info.