BACKGROUND:-. Prostatic diseases are emerging as significant causes of morbidity in middle aged and elderly men globally particularly among Blacks. The increasing availability of surgical services in Nigeria coupled with increasing awareness of healthy living have led to an increase in the number of prostatectomy specimens in histopathology laboratories. Numerous reports on the histopathologic findings in prostate specimens have been issued from several centres in Nigeria, Africa and indeed globally, but only few clinically based and no laboratory based report have emanated from Port Harcourt and the surrounding Niger Delta region. With an aim to contribute to the growing body of knowledge about prostatic disease in Black Africans and provide a platform upon which further research work could be based, we carried out a detailed descriptive histopathological characterization of diseased prostate specimens received in the department 1 of Anatomical Pathology, University of Port Harcourt Teaching Hospital between 1996-2005. Methods:- Biodata information was retrieved from patients request cards. Slides from biopsy specimens were reviewed for disease type and histologically graded according to WHO and Gleason specifications. Associated microscopic findings were also noted. The obtained data was analysed using simple descriptive statistical methods. RESULTS:- Generally the incidence of prostatic diseases is high in Port Harcourt. Prostatitis was found only in association with nodular hyperplasia, prostatic intraepithelial neoplasia, or carcinoma. The mean age of affected patients was 61.5 years and the peak age group was 60-69 years. 2 Incidence of nodular hyperplasia is relatively low and the predominant histologic type is glandulostromal. The peak age group is 60-69 years with a mean of 63.4 years. Morphologically prostatic intraepithelial neoplasias were mainly of high grade pattern. The incidence of Prostate Carcinoma in Port Harcourt is relatively high. The peak age group is 70-79 years with a mean of 70 years. All of these carcinomas were morphologically adenocarcinomas with the majority being of the large acinar variety and of moderate differentiation. Also majority of the carcinomas scored between 7-10 on Gleason grading system with the commonest single score being. Incidental Carcinoma accounted for 17.2% of all carcinomas and 4.4% of the entire specimens. The peak age group of affected patients was 60-69 years. Morphologically these carcinomas were predominantly of large acinar pattern, well differentiated with peak Gleason score of 5-6.