BACKGROUND With the rise in Caesarean section rate in many obstetric centres worldwide, control of blood loss during this procedure is of great importance in order to prevent post partum haemorrhage (PPH). Oxytocin is commonly used drug for this purpose but due to problems such as cost and storage especially in developing countries, there is a need to seek other alternatives. Misoprostol may be considered on account of its good uterine contractility and relatively lower cost among others. OBJECTIVES The main objective of this study was to compare the effectiveness of the drug regimen of rectally administered misoprostol and oxytocin with oxytocin alone in control of blood loss during Caesarean delivery up to 24 hours after delivery. METHODOLOGY The study was a randomised controlled trial involving parturients that had elective Caesarean section at the University of Ilorin Teaching Hospital. They were grouped into two arms. One of the arms had 600µg of misoprostol inserted per rectum while the other arm received 20IU of oxytocin infusion for 4 hours after delivery. Both of the arms had 5IU of oxytocin administered within one minute of delivery of the baby. Intraoperative and postoperative blood loss up to 24hours after delivery, pre and postoperative haematocrit and side effects profiles of the two arms were recorded. Data analysis was done using Statistical Package for Social Sciences software (SPSS) version 21 and a p value set as 0.05 as the level of significance.