Pre-eclampsia is a pregnancy associated syndrome unique to the human. It is the most common medical disorder affecting pregnant women. It occurs in up to 17% of pregnancies and account for 17% of maternal deaths in Nigeria. Abnormal serum lipid levels (dyslipidemia) has been implicated in the pathogenesis of pre-eclampsia. This gives rise to increased oxidative stress and subsequent endothelial damage. The prevalence of dyslipidemia in pregnancy in this environment is not well documented. This study compared the serum lipid profile of pre-eclamptic and normotensive pregnant women. Methods It was a cross sectional (Comparative) study. One hundred and twenty normotensive pregnant women were matched for age, parity and gestational age, with 120 pre-eclamptic pregnant women. Fasting venous blood samples were obtained and analyzed for serum levels of total cholesterol (TC), triglycerides, high-density lipoprotein (HDL) with standard enzymatic method using reagent from BIOLABO, SA 02160. Low-density lipoprotein (LDL-C) was calculated using Friedewald equation: LDL (mmol/L) = TC-HDL-(TG)/2.19, VLDL=TG/5. Data was analyzed using SPSS version 19.