Introduction/Objectives: To compare the efficacy and safety of 25 micrograms versus 50micrograms of intravaginal misoprostol tablets for cervical ripening an induction of labour. Materials and methods: This was a randomized clinical trial involving 120 pregnant women with singleton pregnancy at > 37weeks with valid indication for induction of labour who met the inclusion criteria for the study. They were randomized into 2 groups of 25micrograms and 50micrograms dose regimen of intravaginal misoprostol for prelabour cervical ripening and labour induction with 60 patients in each study group. The respective dose of misoprostol was inserted vaginally (and repeated if necessary, 6hourly with maximum number of doses limited to 4 doses).Labour was managed actively with the use of a partograph.